Alhaji Sinare did not give any reasons for his resignation saying "I have resigned and that is all. I'm not gonna talk about it".
He however said those who wish to know why he resigned should ask another guru in the NDC, Mr. Ato Ahwoi.
But Mr. Ato Ahwoi told Joy News he has no idea what Alhaji Sinare was talking about.
Alhaji Sinare said he is not going to join any other political party because he is not a stomach politician.
"I am not going to join anybody's campaign trail. I'm not stomach politician", he told Joy News.
He told the Joy FM's Super Morning Show host, Kojo Oppong Nkrumah that he was hurt but will not go further.
He said he ought to have resigned from the party long ago because he won primaries in 1999 and was not given the nod.
According to him, the NDC will definitely win the December elections so to take such a decision only buttresses the extent to which he is hurt.
Alhaji Sinare is one of the party's pillars especially in the Zongo communities.
His resignation is therefore seen as a major blow to the party.
The First Deputy General Secretary of the NDC, Elvis Afriyie Ankrah said everything possible must be done to bring Alhaji Sinare back to the party.
He said "Alhaji is a big brother and so if he is hurt the proper thing to do is give him a hearing".
He said he did not have a clue as to what the reason for his resignation could be.
The resignation he said can have a psychological impact on the party and its chances.
Responding to suggestions that the dissociation of the party from comments made by the former first lady created some disunity within the NDC, Afriyie Ankrah said "there is absolutely nothing wrong with disagreeing with someone".
He said although he joined the NDC because of his admiration for former president Rawlings, there were times when he disagreed with him (Rawlings).